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Do not drink plain tap water unless it has been boiled, filtered or chemically treated. Prescribe oral therapy with doxycycline, amoxicillin, or cefuroxime axetil for 28 day in late Lyme disease with arthritis. Doxycycline is surely an effective broad spectrum antibiotic, a member in the tetracycline band of antibiotics. Oral contraceptives or systemic antiandrogens (such as spironolactone) are found in women in whom hormonal treatment could be an effective alternative or adjuvant to antibiotics and oral retinoids. While a bullseye rash is a objective sign of a Lyme infection, many doctors have a tendency to rely on it as being a sole determining factor of whether or never to proceed with testing or possibly a course of antibiotics from a tick bite. If antibiotics no longer can do the trick physicians will attempt the next best treatments for inserting a needle attached to some catheter in the infected diverticula abscesses in order to remove the infected matter and pus. 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